Front-seat side airbags and full-length side-curtain airbags are standard on every 2008 Nissan Altima. Antilock brakes are standard on the 3.5 sedan trims and all coupes, and optional on the 2.5 S sedan. Only the 3.5 trims are eligible for traction control (it's standard) and stability control (optional). In National Highway Traffic Safety Administration crash tests, the Altima sedan received a top five-star rating for its protection of front occupants in frontal and side impacts. Rear passengers received a four-star rating for side impacts.
| Antilock Brakes: Standard | 4 Wheel Antilock Brakes: Standard |
| Depowered Airbag: Standard | Passenger Airbag: Standard |
| Head Airbag: Standard | Side Airbag: Standard |
| Child Safety Seats: Not Available | Traction Control: Not Available |
| Stability Control: Not Available | |
| NHTSA Ratings | |
| Passenger: 5 stars | |
| Driver: 5 stars | |
| Side Impact Front: 5 stars | |
| Side Impact Rear: 5 stars | |
| Rollover Rating: 4 stars | |
| IIHS Ratings | |
| Crash Offset: Not Tested | |
| Bumper Bash: Not Tested |